Cannabis therapies are always with controversy, and there is conflicting evidence on their benefits, however. They have demonstrated tremendous potential for treating medical conditions like cancer, epilepsy, etc. The main problem is that the treatment depends on cannabinoids passing through the blood-brain barrier, while others require rapid absorption into the bloodstream. Conventional delivery systems are not suitable for achieving these goals, which has prompted many companies to develop alternatives.
Here are four alternative delivery system for patients to absorb medical cannabis:
The main issue with swallowed medicine is that they are subject to the so-called first-pass metabolism. And to worsen the situation, it is proven that cannabinoids do not tolerate acidic environments like our stomach.
Lexaria Corp. is developing lipid encapsulation technologies that are designed to protect cannabinoids in acidic environments and maximize absorption. The researchers have processed a mixture of hemp oil, black tea, and select lipids to create a cannabinoid-infused tea that has resulted in as much as a 499% increase in intestinal tissue permeability for cannabidiol (“CBD”) over a concentration matched mixture of just CBD and water.
2. Oral Thin Films
Breath strips are a good way to kill bad breath germs in less than 30 seconds. It turns out that the same type of technology could help efficiently deliver cannabinoids into the bloodstream without the use of water.
CURE Pharmaceutical Corp. is developing an oral thin-film technology with faster onset and greater bioavailability than tablets and other conventional delivery systems. Using a micro-encapsulation process, the active ingredients are shielded by phospholipids and liposomes to deliver higher doses with better flavor masking. These active ingredients bypass the gastric system and are rapidly absorbed into the bloodstream for maximum effectiveness.
Since they’re simply placed the tongue to dissolve, oral thin films are ideally suited for children and elderly patients that may have trouble swallowing pills. They may also help improve compliance since they don’t require water and have improved flavor masking.
3. Sol-Gel Nasal Delivery
Soft gels are known for the easier delivery mechanism as they are familiar to patients, and may contain a variety of different chemicals designed for slow-release and other features that improve the safety and efficacy profile of the active ingredients.
Sol-Gel technology has encapsulated cannabinoids in a soluble form, while nano micelles provide tissue permeation enhancing properties. Local tissue irritation is avoided as cannabinoids are in-solution and can be presented at lower doses. At the same time, Sol-Gels can remain in place for extended periods, which can reduce the administration times to once or twice weekly rather than daily.
4. Chewing Gum
AXIM Biotechnologies Inc. is developing chewing gum, which is based on cannabinoid therapies targeting a wide range of medical conditions. The company’s most advanced program is CanChew Plus® for the treatment of irritable bowel syndrome (“IBS”). Still, it has similar programs targeting multiple sclerosis/pain spasticity, Parkinson’s disease, dementia, restless leg’s syndrome, opioid addiction, tobacco smoking cessation, and other conditions.
In addition to effectively delivering cannabinoids into the bloodstream, chewing gum offers a controlled release via cellulose. It may improve cerebral circulation, stimulate the basal ganglia, reduce stress, improve memory, and offer neuroprotective benefits.
Original post: Casinbis